The study investigated an analysis of library–faculty collaborations in Southwest Universities in Nigeria. Descriptive survey design and multi-stage sampling techniques was adopted and questionnaire as the instrument of data collection, with the total population of the study consisting of 461 lecturers from the faculty of science of six (6) universities covering both public and private ones in the Southwest geo-political zone of the country. Using the Cronbach alpha, the reliability of the test instrument was established at (α=0.85).  Results on the perception of library and faculty relationship were based on different opinion: a significant number of the respondents disagree that academic institution can exist without the library and information services, there were equally significant conflicting responses that disagree that the library and the faculty are not mutually exclusive. The latter opinion was reinforced with subscription to the view that the library and the faculty were mutually exclusive. Areas of collaboration identified included mutual commitment to a mission and collection development, establishment of profitable communication channels, building of strong information literacy infrastructure, involvement of the library in curriculum design and the engagement of the faculty in the formulation of library policies among others. The challenges militating against profitable collaboration between the two cognates were identified while relevant recommendations were made.