There has been uncontrolled increased in the incidences of Kidnapping in recent times in Nigerian expressways and this poses significant threats to regional integration, national security and development. There is dearth of literature among scholars in providing conceptual and empirical nexus between kidnapping hotspots and ungoverned space in Nigerian expressways. This study sought to identify the major kidnapping hotspots in Nigerian expressways and examine the influence of kidnapping hotspots on ungoverned space in Nigerian expressways with a view to providing effective security measures for addressing the menace. Data for the study were collected through in-depth interviews along Kaduna-Abuja expressway and extant review of literature, official reports and statistical bulletin on the nature and trend and pattern kidnapping and nexus between kidnapping and ungoverned space on Nigerian expressways. The paper revealed that the major drivers responsible for the uncontrolled increase in kidnapping along Nigerian expressways were internal conflict, terrorism, insurgency, poverty, unemployment, bad governance, inadequate robust security architecture for effective crime control and prevention, and slow-paced adoption of sophisticated spatially-reference digital technologies for mapping kidnapping hotspots and deployment of security operatives for kidnapping control. The study further revealed a consistent relationship between kidnapping hotspots along Nigerian expressways and ungoverned space, economic loss arising from the payment of ransom, psychological fear of being kidnapped on Nigerian expressways, food security, altered human mobility and regional integration across other parts of Nigeria, distort peri-urban livelihoods, pose threats to national security and development. The paper recommends among others, the need for development of robust security checkpoints through surveillance, patrol vehicles, stop and search operations at some strategic kidnapping hotspots, intelligence information gathering and deployment of joint security task force for prompt response to incidence of kidnapping along Nigerian expressways.