This study examined Influence of Media Literacy Skills (MLS), on use of Social Media (SM) by undergraduates in two universities in Delta State. The descriptive survey design of the correlational type was adopted and population was undergraduates from Delta State University (DELSU-22,125) and Michael and Cecilia Ibru University (MCIU-88), Delta State. A two-stage random sampling technique was used to get the sample size of 340 for data collection using questionnaire data was analysed using frequencies, mean, standard deviation, Pearson’s Product Moment Correlation. The 200 level students 159 (52.3%) participated more in DELSU and 300 level 9 (81.8%) in MCIU. Results revealed high MLS in DELSU (=49.05) and MCIU (=51.27). Majority needed information on SM to pass examination (DELSU-=3.63, MCIU==3.45), used WhatsApp (DELSU-=3.72; MCIU-=3.82), chat with friends (DELSU-=3.64; MCIU-=3.73) and daily (DELSU-78.9% and MCIU- 54.5%). The major challenges were expensive Internet subscription in DELSU (=3.43) and poor internet connection in MCIU (=3.18). MLS significantly and positively predicted SM use in DELSU (r=.306**; p< 0.01) and MCIU (r = .604*; p< 0.05). The study concludes that MLS determined SM use by the undergraduates. Therefore, it was recommended that Information and Communication Technology unit of the universities should liaise with lecturers and librarians in organising training on the appropriate use of social media by undergraduates.