The usefulness of legal frameworks in the task of human rights protection remains a key subject amongst nations of the world. This article assessed the protection of human rights in the compulsion of the Covid-19 lock-down experience in Nigeria. It looked at the prevailing reality of human rights enforcement in Nigeria, how Covid-19 lock-down experience affected human rights protection and what government can do to avert future implications. Using secondary sources, the study found that issues of human rights never got protection as supposed during the Covid-19 experience in Nigeria. Marxist criminology was adopted in the analysis of variables within the context of the Nigerian society. In averting this challenge in the future, the study recommends respect for world protocols regarding human rights, overwhelming reform of the criminal justice architecture to suit global concern for human rights protection, evolve a deliberate emergency plan that conveniently tackles pandemic experiences, government should ignite massive awareness campaigns and enlightenment programmes on human rights issues as contained in the constitution and rekindle the spirit of patriotic consciousness and professionalism in public authorities.