This study was carried out to determine the compliance with covid-19 guidelines and protocols by academic libraries for safety operations in Niger State. The study showed that there is high level of compliance with NCDC guidelines in the operation of academic libraries in Niger State. Although it was discovered that much is not done on the aspects of training the library personnel on proactiveness to covid-19, and in-placing of proper channel of communication, consultation and reporting cases. On the basis of these findings, the study concluded that academic libraries in Niger State are proactive and taking appropriate actions aimed at mitigating the spread of covid-19 in the area. However, the study recommended that training and re-training of library personnel on proactive ways to covid-19 especially on first aid exercise, provision of more number of facilities to the libraries should be provided and library taskforce on covid-19 should be motivated to rise up to their responsibility of supervision.